Semaglutide is a once a week injection to help with chronic weight management. It works best when combined with a healthy diet and exercise. Weekly injections are given subcutaneously in the thigh, stomach, or arm fat. It works as an appetite suppressant, helping to control cravings, support healthy portion control, and encourage weight loss. Semaglutide works by mimicking certain peptides in the brain that regulate your food intake tolerance and appetite.